|
KMID : 1141420220270020162
|
|
Korean Journal of Healthcare-associated Infection Control Prevention
2022 Volume.27 No. 2 p.162 ~ p.167
|
|
|
Outbreaks of Carbapenem Resistant Enterobacterales (CRE) According to the Type of Hospitals
|
|
Yun Su-Jung
Kwon Sun-Mok
Hur Eun-Seon
Park So-Jung
Lee Yoon-Hee
Pyeon Hui-Su
Jeong Il-Hyung
|
|
|
Abstract
|
|
|
Background: Carbapenem-resistant Enterobacterales (CRE) are increasing rapidly worldwide, posing a major threat to global health. This study aimed to identify the epidemiological characteristics of CRE isolated in Gyeonggi-do according to hospital type.
Methods: We conducted antibiotic susceptibility and genetic tests for carbapenemase-producing Enterobacterales (CPE) among 1,243 clinical isolates of CRE from Gyeonggi-do in 2019. CRE strains were identified using MALDI-TOF (Microflex, BRUKER, Germany), and antimicrobial susceptibility tests were performed using the broth microdilution method, according to the CLSI guidelines. Genetic testing of the CPE type was performed for KPC, NDM, OXA-48, IMP, VIM, and GES.
Results: Most CRE infections in Gyeonggi-do occurred in general hospitals (60.9%) and long-term care hospitals (27.8%). While the proportion of the CPE group in general hospitals was low (55.7%), 85.0% of CRE isolates in long-term care hospitals were identified in the CPE group. In the CPE group, the proportion of CRE isolates above the minimum inhibitory concentration of carbapenem namely meropenem, imipenem, and doripenem was 76.0%, 90.2%, and 66.5%, respectively. The non-CPE group showed a relatively low resistance percentage (44.6% [meropenem], 27.6% [imipenem], and 25.2% [doripenem]) compared to the CPE group. Furthermore, we found a correlation between CPE genes and carbapenem resistance rate on the Kruskal?Wallis test (P≤0.05).
Conclusion: Carbapenem resistance rate and the genetic characteristics of CRE isolates differed according to the type of hospital in which they occurred. The high proportion of the CPE group in long-term care hospitals indicates the need for more attention to strict infection control in these hospitals.
|
|
|
KEYWORD
|
|
|
Carbapenem-resistant Enterobacterales, Carbapenemase-producing Enterobacterales, Long-term care hospital, General hospital
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|